Is CoQ a membrane stabilizer?

被引:13
作者
Clarke, Catherine F. [1 ,2 ]
Rowat, Amy C. [2 ,3 ]
Gober, James W. [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA
关键词
COENZYME Q(10);
D O I
10.1038/nchembio.1478
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coenzyme Q(10) is an essential lipid in aerobic respiratory metabolism and a membrane antioxidant. A new function is revealed for CoQ; as a membrane-stabilizing agent that enhances resistance of bacterial cell and liposome membranes to salt stress.
引用
收藏
页码:242 / 243
页数:2
相关论文
共 10 条
[1]   Heterogeneity of Coenzyme Q10 Deficiency Patient Study and Literature Review [J].
Emmanuele, Valentina ;
Lopez, Luis C. ;
Berardo, Andres ;
Naini, Ali ;
Tadesse, Saba ;
Wen, Bing ;
D'Agostino, Erin ;
Solomon, Martha ;
DiMauro, Salvatore ;
Quinzii, Catarina ;
Hirano, Michio .
ARCHIVES OF NEUROLOGY, 2012, 69 (08) :978-983
[2]   Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10 [J].
Gasser, David L. ;
Winkler, Cheryl A. ;
Peng, Min ;
An, Ping ;
McKenzie, Louise M. ;
Kirk, Gregory D. ;
Shi, Yuchen ;
Xie, Letian X. ;
Marbois, Beth N. ;
Clarke, Catherine F. ;
Kopp, Jeffrey B. .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2013, 305 (08) :F1228-F1238
[3]   Functional role of mitochondrial respiratory supercomplexes [J].
Genova, Maria Luisa ;
Lenaz, Giorgio .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2014, 1837 (04) :427-443
[4]   Do sterols reduce proton and sodium leaks through lipid bilayers? [J].
Haines, TH .
PROGRESS IN LIPID RESEARCH, 2001, 40 (04) :299-324
[5]   Localization of coenzyme Q10 in the center of a deuterated lipid membrane by neutron diffraction [J].
Hauss, T ;
Dante, S ;
Haines, TH ;
Dencher, NA .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2005, 1710 (01) :57-62
[6]   Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants [J].
He, Cuiwen H. ;
Xie, Letian X. ;
Allan, Christopher M. ;
Tran, UyenPhuong C. ;
Clarke, Catherine F. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2014, 1841 (04) :630-644
[7]   Lipid-lipid interactions in bilayer membranes: Married couples and casual liaisons [J].
Quinn, Peter J. .
PROGRESS IN LIPID RESEARCH, 2012, 51 (03) :179-198
[8]   Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli [J].
Sevin, Daniel C. ;
Sauer, Uwe .
NATURE CHEMICAL BIOLOGY, 2014, 10 (04) :266-+
[9]   Metabolism and function of coenzyme Q [J].
Turunen, M ;
Olsson, J ;
Dallner, G .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2004, 1660 (1-2) :171-199
[10]   Bacterial Osmoregulation: A Paradigm for the Study of Cellular Homeostasis [J].
Wood, Janet M. .
ANNUAL REVIEW OF MICROBIOLOGY, VOL 65, 2011, 65 :215-238