A scored human protein-protein interaction network to catalyze genomic interpretation

被引：438

作者：

Li, Taibo ^{[1
,2
,3
]}

Wernersson, Rasmus ^{[4
,5
]}

Hansen, Rasmus B. ^{[4
]}

Horn, Heiko ^{[1
,2
,6
]}

Mercer, Johnathan ^{[1
,2
]}

Slodkowicz, Greg ^{[5
,9
]}

Workman, Christopher T. ^{[5
]}

Rigina, Olga ^{[5
]}

Rapacki, Kristoffer ^{[5
]}

Staerfeldt, Hans H. ^{[5
]}

Brunak, Soren ^{[7
]}

Jensen, Thomas S. ^{[4
]}

Lage, Kasper ^{[1
,2
,6
,8
]}

机构：

[1] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA

[2] Broad Inst & MIT Harvard, Cambridge, MA 02138 USA

[3] MIT, Cambridge, MA 02138 USA

[4] Int A S, Lyngby, Denmark

[5] Tech Univ Denmark, Ctr Biol Sequence Anal, Lyngby, Denmark

[6] Harvard Med Sch, Boston, MA USA

[7] Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Copenhagen, Denmark

[8] Univ Copenhagen, Mental Hlth Ctr Sct Hans, Inst Biol Psychiat, Roskilde, Denmark

[9] EMBL, European Bioinformat Inst, Wellcome Trust Genome Campus, Cambridge, England

来源：

NATURE METHODS | 2017年 / 14卷 / 01期

关键词：

GENETIC ARCHITECTURE; INTERACTION DATABASE; WIDE ASSOCIATION; PATTERNS; RESOURCE; INSIGHTS;

D O I：

10.1038/nmeth.4083

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.

引用

页码：61 / 64

页数：4

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