Pleiotropic Effects of Platelet P2Y12 Receptor Inhibitors: Fact or Fiction?

被引：5

作者：

Moulias, Athanasios ^{[1
]}

Xanthopoulou, Ioanna ^{[1
]}

Alexopoulos, Dimitrios ^{[1
]}

机构：

[1] Patras Univ Hosp, Dept Cardiol, Patras 26500, Greece

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 28期

关键词：

Clopidogrel; off-target effects; pleiotropic; P2Y12; inhibitors; prasugrel; ticagrelor; CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; P-SELECTIN EXPRESSION; C-REACTIVE PROTEIN; INFLAMMATORY MARKERS; ACTIVE METABOLITE; ADENOSINE-DIPHOSPHATE; CLOPIDOGREL PRETREATMENT; ANTIPLATELET THERAPY; ENDOTHELIAL FUNCTION;

D O I：

10.2174/1381612820666140414211543

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

P2Y(12) inhibitors constitute an essential part of the antithrombotic treatment, with proven clinical benefit in acute coronary syndromes and after percutaneous coronary interventions. Substantial evidence has emerged that, apart from their primary antiplatelet action, P2Y(12) receptor inhibitors exhibit several off-target effects. In this review, we present the supporting evidence of P2Y(12) inhibitors' pleiotropic actions, discuss their clinical implications and underscore the necessity for further research on this issue.

引用

页码：4597 / 4604

页数：8

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