Pleiotropic Effects of Platelet P2Y12 Receptor Inhibitors: Fact or Fiction?

被引：5
作者：
Moulias, Athanasios [1 ]
Xanthopoulou, Ioanna [1 ]
Alexopoulos, Dimitrios [1 ]
机构：
[1] Patras Univ Hosp, Dept Cardiol, Patras 26500, Greece
来源：
CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 28期
关键词：
Clopidogrel; off-target effects; pleiotropic; P2Y12; inhibitors; prasugrel; ticagrelor; CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; P-SELECTIN EXPRESSION; C-REACTIVE PROTEIN; INFLAMMATORY MARKERS; ACTIVE METABOLITE; ADENOSINE-DIPHOSPHATE; CLOPIDOGREL PRETREATMENT; ANTIPLATELET THERAPY; ENDOTHELIAL FUNCTION;
D O I：
10.2174/1381612820666140414211543
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P2Y(12) inhibitors constitute an essential part of the antithrombotic treatment, with proven clinical benefit in acute coronary syndromes and after percutaneous coronary interventions. Substantial evidence has emerged that, apart from their primary antiplatelet action, P2Y(12) receptor inhibitors exhibit several off-target effects. In this review, we present the supporting evidence of P2Y(12) inhibitors' pleiotropic actions, discuss their clinical implications and underscore the necessity for further research on this issue.
引用
收藏
页码：4597 / 4604
页数：8
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共 85 条
  • [1] The effect of long-term clopidogrel use on neointimal formation after percutaneous coronary intervention
    Akbulut, M
    Ozbay, Y
    Karaca, I
    Ilkay, E
    Gundogdu, Z
    Arslan, N
    [J]. CORONARY ARTERY DISEASE, 2004, 15 (06) : 347 - 352
  • [2] Differential Effect of Ticagrelor Versus Prasugrel on Coronary Blood Flow Velocity in Patients With Non-ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: An Exploratory Study
    Alexopoulos, Dimitrios
    Moulias, Athanasios
    Koutsogiannis, Nikolaos
    Xanthopoulou, Ioanna
    Kakkavas, Apostolos
    Mavronasiou, Eleni
    Davlouros, Periklis
    Hahalis, George
    [J]. CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2013, 6 (03) : 277 - 283
  • [3] Thienopyridines, but Not Elinogrel, Result in Off-Target Effects at the Vessel Wall That Contribute to Bleeding
    Andre, Patrick
    DeGuzman, Francis
    Haberstock-Debic, Helena
    Mills, Scott
    Pak, Yvonne
    Inagaki, Mayuko
    Pandey, Anjali
    Hollenbach, Stanley
    Phillips, David R.
    Conley, Pamela B.
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 338 (01) : 22 - 30
  • [4] Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease
    Angiolillo, DJ
    Fernandez-Ortiz, A
    Bernardo, E
    Ramírez, C
    Sabaté, M
    Jimenez-Quevedo, P
    Hernández, R
    Moreno, R
    Escaned, J
    Alfonso, F
    Bañuelos, C
    Costa, MA
    Bass, TA
    Macaya, C
    [J]. DIABETES, 2006, 55 (03) : 780 - 784
  • [5] Effect of Long-Term Clopidogrel Treatment on Platelet Function and Inflammation in Patients Undergoing Coronary Arterial Stenting
    Antonino, Mark J.
    Mahla, Elisabeth
    Bliden, Kevin P.
    Tantry, Udaya S.
    Gurbel, Paul A.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (11) : 1546 - 1550
  • [6] Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease -: art. no. e1
    Azar, RR
    Kassab, R
    Zoghbi, A
    Aboujaoudé, S
    El-Osta, H
    Ghorra, P
    Germanos, M
    Salamé, E
    [J]. AMERICAN HEART JOURNAL, 2006, 151 (02) : 521.e1 - 521.e4
  • [7] Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP
    Ben Addi, Abduelhakem
    Cammarata, Dorothee
    Conley, Pamela B.
    Boeynaems, Jean-Marie
    Robaye, Bernard
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (10) : 5900 - 5906
  • [8] Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events
    Bhatt, Deepak L.
    Stone, Gregg W.
    Mahaffey, Kenneth W.
    Gibson, C. Michael
    Steg, P. Gabriel
    Hamm, Christian W.
    Price, Matthew J.
    Leonardi, Sergio
    Gallup, Dianne
    Bramucci, Ezio
    Radke, Peter W.
    Widimsky, Petr
    Tousek, Frantisek
    Tauth, Jeffrey
    Spriggs, Douglas
    McLaurin, Brent T.
    Angiolillo, Dominick J.
    Genereux, Philippe
    Liu, Tiepu
    Prats, Jayne
    Todd, Meredith
    Skerjanec, Simona
    White, Harvey D.
    Harrington, Robert A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (14) : 1303 - 1313
  • [9] Ticagrelor Increases Adenosine Plasma Concentration in Patients With an Acute Coronary Syndrome
    Bonello, Laurent
    Laine, Marc
    Kipson, Nathalie
    Mancini, Julien
    Helal, Olfa
    Fromonot, Julien
    Gariboldi, Vlad
    Condo, Jocelyne
    Thuny, Franck
    Frere, Corinne
    Camoin-Jau, Laurence
    Paganelli, Franck
    Dignat-George, Francoise
    Guieu, Regis
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (09) : 872 - 877
  • [10] Level of Adenosine Diphosphate Receptor P2Y12 Blockade During Percutaneous Coronary Intervention Predicts the Extent of Endothelial Injury, Assessed by Circulating Endothelial Cell Measurement
    Bonello, Laurent
    Harhouri, Karim
    Sabatier, Florence
    Camoin-Jau, Laurence
    Arnaud, Laurent
    Baumstarck-Barrau, Karine
    Ait-Mokhtar, Omar
    Roubille, Francois
    Piot, Christophe
    Lesavre, Nathalie
    Paganelli, Franck
    Dignat-George, Francoise
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (13) : 1024 - 1031
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