Obesity Doubles Mortality in Patients Hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 in Paris Hospitals, France: A Cohort Study on 5,795 Patients

被引:72
作者
Czernichow, Sebastien [1 ,2 ,3 ]
Beeker, Nathanael [1 ,4 ]
Rives-Lange, Claire [1 ,2 ,3 ]
Guerot, Emmanuel [1 ,5 ]
Diehl, Jean-Luc [1 ,5 ]
Katsahian, Sandrine [1 ,6 ,7 ]
Hulot, Jean-Sebastien [1 ,8 ,9 ]
Poghosyan, Tigran [1 ,10 ]
Carette, Claire [1 ,2 ,8 ,9 ]
Jannot, Anne-Sophie [1 ,6 ,7 ]
机构
[1] Univ Paris, Paris, France
[2] Hop Europeen Georges Pompidou, AP HP, Specialized Obes Ctr, Dept Nutr, Paris, France
[3] Inst Natl Sante & Rech Med, Epidemiol & Biostat Sorbonne Paris City Ctr, UMR1153, Paris, France
[4] Hop Cochin, AP HP, Clin Res Unit, Paris, France
[5] Hop Europeen Georges Pompidou, AP HP, Dept Intens Care Med, Paris, France
[6] Hop Europeen Georges Pompidou, AP HP, Dept Med Informat Biostat & Publ Hlth, Paris, France
[7] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, Dept Informat Sci Support Personalized Med,INSERM, F-75006 Paris, France
[8] Hop Europeen Georges Pompidou, AP HP, Clin Invest Ctr 1418, Paris, France
[9] Hop Europeen Georges Pompidou, AP HP, Cardiovasc Renal Transplants & Neurovasc Med Univ, Paris, France
[10] Hop Europeen Georges Pompidou, AP HP, Dept Digest Oncol & Bariatr Surg, Paris, France
关键词
RISK;
D O I
10.1002/oby.23014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Preliminary data from different cohorts of small sample size or with short follow-up indicate poorer prognosis in people with obesity compared with other patients. This study aims to precisely describe the strength of association between obesity in patients hospitalized with coronavirus disease 2019 (COVID-19) and mortality and to clarify the risk according to usual cardiometabolic risk factors in a large cohort. Methods This is a prospective cohort study including 5,795 patients aged 18 to 79 years hospitalized from February 1 to April 30, 2020, in the Paris area, with confirmed infection by severe acute respiratory syndrome coronavirus 2. Adjusted regression models were used to estimate the odds ratios (ORs) and 95% CIs for the mortality rate at 30 days across BMI classes, without and with imputation for missing BMI values. Results Eight hundred ninety-one deaths had occurred at 30 days. Mortality was significantly raised in people with obesity, with the following ORs for BMI of 30 to 35 kg/m(2), 35 to 40 kg/m(2), and >40 kg/m(2): 1.89 (95% CI: 1.45-2.47), 2.79 (95% CI: 1.95-3.97), and 2.55 (95% CI: 1.62-3.95), respectively (18.5-25 kg/m(2) was used as the reference class). This increase holds for all age classes. Conclusions Obesity doubles mortality in patients hospitalized with COVID-19.
引用
收藏
页码:2282 / 2289
页数:8
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