PEG-conjugated pyrrole-based polymers: one-pot multicomponent synthesis and self-assembly into soft nanoparticles for drug delivery

被引：33

作者：

Moquin, Alexandre ^{[1
,2
]}

Hanna, Ramez ^{[1
]}

Liang, Tongyue ^{[1
]}

Erguven, Huseyin ^{[1
]}

Gran, Evan Rizzel ^{[2
]}

Arndtsen, Bruce A. ^{[1
]}

Maysinger, Dusica ^{[2
]}

Kakkar, Ashok ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada

[2] McGill Univ, Dept Pharmacol & Therapeut, 3655 Promenade Sir William Osler, Montreal, PQ H3G 1Y6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 66期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CELASTROL; RESVERATROL; POLYPYRROLE; GROWTH; THUNDER; RELEASE; CELLS;

D O I：

10.1039/c9cc04000e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyethylene glycol grafted pyrrole-based conjugated polymers are synthesized through a one-pot multicomponent methodology, the self-assemblies of which enable nanoparticle size-selective encapsulation of drug molecules and their sustained release. Efficient loading of curcumin through drug-nanoparticle core interactions is probed using FRET, and the inherently fluorescent nature of polypyrrole could be used to detect these nanocarriers intracellularly.

引用

页码：9829 / 9832

页数：4

共 24 条

[11] A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles [J].

Leitch, David C. ;

Kayser, Laure V. ;

Han, Zhi-Yong ;

Siamaki, Ali R. ;

Keyzer, Evan N. ;

Gefen, Ashley ;

Arndtsen, Bruce A. .

NATURE COMMUNICATIONS, 2015, 6

[12] Amphiphilic polypyrrole-poly(Schiff base) copolymers with poly(ethylene glycol) side chains: synthesis, properties and applications [J].

Molina, Brenda G. ;

Cianga, Luminita ;

Bendrea, Anca-Dana ;

Cianga, Ioan ;

del Valle, Luis J. ;

Estrany, Francesc ;

Aleman, Carlos ;

Armelin, Elaine .

POLYMER CHEMISTRY, 2018, 9 (31) :4218-4232

[13] Modular Mesoionics: Understanding and Controlling Regioselectivity in 1,3-Dipolar Cycloadditions of Munchnone Derivatives [J].

Morin, Marie S. T. ;

St-Cyr, Daniel J. ;

Arndtsen, Bruce A. ;

Krenske, Elizabeth H. ;

Houk, K. N. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (46) :17349-17358

[14] Application of polypyrrole for the creation of immunosensors [J].

Ramanaviciene, A ;

Ramanavicius, A .

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2002, 32 (03) :245-252

[15] Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively? [J].

Ravindran, Jayaraj ;

Prasad, Sahdeo ;

Aggarwal, Bharat B. .

AAPS JOURNAL, 2009, 11 (03) :495-510

[16] Micellization of block copolymers [J].

Riess, G .

PROGRESS IN POLYMER SCIENCE, 2003, 28 (07) :1107-1170

[17] Celastrol: Molecular targets of Thunder God Vine [J].

Salminen, Antero ;

Lehtonen, Marko ;

Paimela, Tuomas ;

Kaarniranta, Kai .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 394 (03) :439-442

[18] Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release [J].

Samanta, Devleena ;

Meiser, Jana L. ;

Zare, Richard N. .

NANOSCALE, 2015, 7 (21) :9497-9504

[19] Enhanced growth inhibition effect of Resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levels [J].

Shao, Junfei ;

Li, Xiaolin ;

Lu, Xiaowei ;

Jiang, Chen ;

Hu, Yong ;

Li, Qingping ;

You, Yongping ;

Fu, Zhen .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2009, 72 (01) :40-47

[20]

Theato P., 2015, MULTICOMPONENT SEQUE, DOI DOI 10.1021/acs.orglett.5b01994

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