PEG-conjugated pyrrole-based polymers: one-pot multicomponent synthesis and self-assembly into soft nanoparticles for drug delivery

被引：33

作者：

Moquin, Alexandre ^{[1
,2
]}

Hanna, Ramez ^{[1
]}

Liang, Tongyue ^{[1
]}

Erguven, Huseyin ^{[1
]}

Gran, Evan Rizzel ^{[2
]}

Arndtsen, Bruce A. ^{[1
]}

Maysinger, Dusica ^{[2
]}

Kakkar, Ashok ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada

[2] McGill Univ, Dept Pharmacol & Therapeut, 3655 Promenade Sir William Osler, Montreal, PQ H3G 1Y6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 66期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CELASTROL; RESVERATROL; POLYPYRROLE; GROWTH; THUNDER; RELEASE; CELLS;

D O I：

10.1039/c9cc04000e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyethylene glycol grafted pyrrole-based conjugated polymers are synthesized through a one-pot multicomponent methodology, the self-assemblies of which enable nanoparticle size-selective encapsulation of drug molecules and their sustained release. Efficient loading of curcumin through drug-nanoparticle core interactions is probed using FRET, and the inherently fluorescent nature of polypyrrole could be used to detect these nanocarriers intracellularly.

引用

页码：9829 / 9832

页数：4

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