Enantioselective Hydrogenation of N-H Imines

被引：146

作者：

Hou, Guohua ^{[3
]}

Gosselin, Francis ^{[1
,2
]}

Li, Wei ^{[3
]}

McWilliams, Christopher ^{[1
]}

Sun, Yongkui ^{[1
]}

Weisel, Mark ^{[1
]}

O'Shea, Paul D. ^{[2
]}

Chen, Cheng-yi ^{[1
]}

Davies, Ian W. ^{[1
]}

Zhang, Xumu ^{[3
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

[2] Merck Frosst Ctr Therapeut Res, Dept Proc Res, Kirkland, PQ H9H 3L1, Canada

[3] Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 29期

基金：

美国国家卫生研究院;

关键词：

CATALYZED ASYMMETRIC HYDROGENATION; CHIRAL TITANOCENE CATALYST; ACYCLIC IMINES; EFFICIENT SYNTHESIS; LIGANDS; ENAMINES; COMPLEXES; TOSYLIMINES; DERIVATIVES; RHODIUM(I);

D O I：

10.1021/ja903319r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitrites and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v using Ir-(S,S)-f binaphane as catalyst provides chiral amines 4a-4v in 90-95% yield with enantioselectivities up to 95% ee.

引用

页码：9882 / +

页数：3

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