Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role?

被引：47

作者：

Aguirre, Clara ^{[1
]}

Meca-Lallana, Virginia ^{[1
]}

Barrios-Blandino, Ana ^{[2
]}

del Rio, Beatriz ^{[1
]}

Vivancos, Jose ^{[3
]}

机构：

[1] Hosp Univ La Princesa, Dept Neurol, Multiple Sclerosis Unit, Madrid, Spain

[2] Hosp Univ La Princesa, Dept Infect Dis, Madrid, Spain

[3] Hosp Univ La Princesa, Dept Neurol, Madrid, Spain

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2020年 / 44卷

关键词：

Multiple Sclerosis; COVID-19; SARS-CoV-2; Natalizumab; Integrins;

D O I：

10.1016/j.msard.2020.102250

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The disease caused by the new coronavirus SARS-CoV-2 (COVID-19) is currently spread worldwide. Recent data supports SARS-CoV-2 may use integrins to enter human cells. Therefore, anti-integrins therapies might be an alternative against the infection. Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking alpha 4-integrin. We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. We postulate this may be due to the blockade of integrins induced by natalizumab.

引用

页数：2

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