The Tissue Response and Degradation of Electrospun Poly(ε-caprolactone)/Poly(trimethylene-carbonate) Scaffold in Subcutaneous Space of Mice

被引：18

作者：

Jiang, Tao ^{[1
,2
]}

Zhang, Guoquan ^{[1
]}

He, Wentong ^{[1
]}

Li, Hui ^{[1
]}

Jin, Xun ^{[1
]}

机构：

[1] Logist Univ Chinese Peoples Armed Police Forces, Dept Histol & Embryol, Tianjin 300309, Peoples R China

[2] Tianjin Key Lab Cardiovasc Remodeling & Target Or, Tianjin 300162, Peoples R China

来源：

JOURNAL OF NANOMATERIALS | 2014年 / 2014卷

关键词：

IN-VIVO; EPSILON-CAPROLACTONE; CARBONATE); POLYCAPROLACTONE; IMPLANTS; BEHAVIOR;

D O I：

10.1155/2014/837695

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Due to the advantage of controllability on the mechanical property and the degradation rates, electrospun PCL/PTMC nanofibrous scaffold could be appropriate for vascular tissue engineering. However, the tissue response and degradation of electrospun PCL/PTMC scaffold in vivo have never been evaluated in detail. So, electrospun PCL/PTMC scaffolds with different blend ratios were prepared in this study. Mice subcutaneous implantation showed that the continuous degradation of PCL/PTMC scaffolds induced a lasted macrophage-mediated foreign body reaction, which could be in favor of the tissue regeneration in graft.

引用

页数：7

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