Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer's Disease: Metal-Amyloid-β

被引：17

作者：

Nam, Geewoo ^{[1
,2
]}

Lim, Mi Hee ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea

[2] UNIST, Dept Chem, Ulsan 44919, South Korea

来源：

CHEMISTRY LETTERS | 2019年 / 48卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Amyloid-beta; Metal ions; Metal-amyloid-beta; TARGETING A-BETA; HYDROGEN-PEROXIDE; PRECURSOR PROTEIN; IN-VITRO; SECONDARY NUCLEATION; PEPTIDE AGGREGATION; SMALL MOLECULES; CHEMICAL TOOLS; COPPER; ZINC;

D O I：

10.1246/cl.190281

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Both amyloid-beta (A beta) and metal ions are implicated in the pathology of Alzheimer's disease (AD). Research efforts elucidating the pathogenic roles of these two biological components denote a connection between them. This highlight review presents the current understanding of A beta and metal ions in AD and their relationship prompting a hybrid concept: metal-bound A beta (metal-A beta).

引用

页码：951 / 960

页数：10

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