Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer's Disease: Metal-Amyloid-β

被引：16
|
作者：
Nam, Geewoo [1 ,2 ]
Lim, Mi Hee [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea
[2] UNIST, Dept Chem, Ulsan 44919, South Korea
来源：
CHEMISTRY LETTERS | 2019年 / 48卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Amyloid-beta; Metal ions; Metal-amyloid-beta; TARGETING A-BETA; HYDROGEN-PEROXIDE; PRECURSOR PROTEIN; IN-VITRO; SECONDARY NUCLEATION; PEPTIDE AGGREGATION; SMALL MOLECULES; CHEMICAL TOOLS; COPPER; ZINC;
D O I：
10.1246/cl.190281
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Both amyloid-beta (A beta) and metal ions are implicated in the pathology of Alzheimer's disease (AD). Research efforts elucidating the pathogenic roles of these two biological components denote a connection between them. This highlight review presents the current understanding of A beta and metal ions in AD and their relationship prompting a hybrid concept: metal-bound A beta (metal-A beta).
引用
收藏
页码：951 / 960
页数：10
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