COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality

被引:46
|
作者
Sharma, Prateek [1 ,2 ]
Behl, Tapan [1 ]
Sharma, Neelam [1 ]
Singh, Sukhbir [1 ]
Grewal, Ajmer Singh [3 ]
Albarrati, Ali [4 ]
Albratty, Mohammed [5 ]
Meraya, Abdulkarim M. [6 ]
Bungau, Simona [7 ,8 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India
[2] Govt Pharm Coll, Nagrota Bagwan, Kangra, Himachal Prades, India
[3] Guru Gobind Singh Coll Pharm, Yamunanagar, Haryana, India
[4] King Saud Univ, Coll Appl Med Sci, Rehabil Hlth Sci, Riyadh, Saudi Arabia
[5] Jazan Univ, Coll Pharm, Dept Pharmaceut Chem, Jazan, Saudi Arabia
[6] Jazan Univ, Coll Pharm, Dept Clin Pharm, Pharm Practice Res Unit, Jazan, Saudi Arabia
[7] Univ Oradea, Fac Med, Dept Pharm, Pharm, Oradea, Romania
[8] Univ Oradea, Doctoral Sch Biomed Sci, Oradea, Romania
关键词
COVID-19; Diabetes mellitus; SARS-CoV-2; Glucose homeostasis; Angiotensin-converting; enzyme inhibitors; RESPIRATORY SYNDROME CORONAVIRUS; PLASMA-GLUCOSE; MERS-COV; MELLITUS; HYPERGLYCEMIA; GLUCOKINASE; PREVALENCE; ACTIVATORS; INFLUENZA; INFECTION;
D O I
10.1016/j.biopha.2022.113089
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetes is a condition that affects a large percentage of the population and it is the leading cause of a wide range of costly complications. Diabetes is linked to a multi-fold increase in mortality and when compared to non diabetics, the intensity and prevalence of COVID-19 ailment among diabetic individuals are more. Since its discovery in Wuhan, COVID-19 has grown rapidly and shown a wide range of severity. Temperature, lymphopenia, non-productive cough, dyspnoea, and tiredness are recognized as the characteristic of individuals infected with COVID-19 disease. In COVID-19 patients, diabetes and other related comorbidities are substantial predictors of disease and mortality. According to a recent study, SARS-CoV-2 (the virus responsible for covid-19 disease) may also lead to direct pancreatic harm, which could aggravate hyperglycemia and potentially cause the establishment of diabetes in formerly non-diabetic individuals. This bidirectional association of COVID-19 and diabetes load the burden on health care professionals throughout the world. It is recommended that gliptin medications be taken moderately, blood glucose levels must be kept under control, ACE inhibitors should be used in moderation, decrease the number of avoidable hospitalizations, nutritional considerations, and some other prevention measures, such as immunization, are highly recommended. SARS-CoV-2 may cause pleiotropic changes in glucose homeostasis, which could exacerbate the pathophysiology of pre-existing diabetes or result in new disease processes.
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页数:10
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