From paramutation to human disease: RNA-mediated heredity

被引：10
|
作者：
Rassoulzadegan, Minoo [1 ]
Cuzin, Francois [1 ]
机构：
[1] Univ Nice Sophia Antipolis, INSERM, U1091, CNRS,U7277, F-06034 Nice, France
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 44卷
关键词：
Epigenetic; Noncoding RNA; Heredity; Sperm; Paramutation; HIGH-FAT DIET; PRENATAL EXPOSURE; DUTCH FAMINE; R LOCUS; INHERITANCE; MICE; MAIZE; MOUSE; METHYLATION; LIFE;
D O I：
10.1016/j.semcdb.2015.08.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：47 / 50
页数：4
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