Proteomics and irritable bowel syndrome

被引：5

作者：

Tsigaridas, Athanasios ^{[1
]}

Papanikolaou, Ioannis S. ^{[2
,3
]}

Vaiopoulou, Anna ^{[4
]}

Anagnostopoulos, Athanasios K. ^{[5
]}

Viazis, Nikos ^{[1
]}

Karamanolis, George ^{[6
]}

Karamanolis, Dimitrios G. ^{[1
]}

Tsangaris, George T. ^{[5
]}

Mantzaris, Gerasimos J. ^{[1
]}

Gazouli, Maria ^{[4
]}

机构：

[1] Evangelismos Med Ctr, Gastroenterol Unit, Athens, Greece

[2] Univ Athens, Hepatogastroenterol Unit, Dept Internal Med 2, Athens, Greece

[3] Univ Athens, Med Sch, Res Inst, Attikon Univ,Gen Hosp, Athens, Greece

[4] Univ Athens, Dept Basic Med Sci, Lab Biol, Med Sch, Michalakopoulou 176, Athens 11527, Greece

[5] Acad Athens IIBEAA, Biomed Res Fdn, Prote Res Unit, Athens, Greece

[6] Univ Athens, Aretaieio Univ Hosp, Gastroenterol Unit, Dept Surg 2,Med Sch, Athens, Greece

来源：

EXPERT REVIEW OF PROTEOMICS | 2017年 / 14卷 / 05期

关键词：

Genetics; IBS; pathophysiology; proteomics; biomarkers; VISCERAL HYPERSENSITIVITY; COLONIC HYPERMOTILITY; SYNDROME IBS; PROTEIN; BIOMARKERS; ACTIVATION; REVEALS; INTERLEUKIN-6; EPIDEMIOLOGY; PATHOGENESIS;

D O I：

10.1080/14789450.2017.1317600

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction: Irritable bowel syndrome (IBS) is a gastrointestinal disease that according to Rome IV criteria is subdivided into four subtypes. The pathophysiology of this disease is not well understood due to numerous factors playing multiple roles in disease development, such as diet, stress and hormones. IBS has a variety of symptoms and overlaps with many other gastrointestinal and non-gastrointestinal diseases.Area covered: This review aims to present an overview of implementation of proteomics in experimental studies in the field of IBS.Expert commentary: Proteomics is commonly used for biomarker discovery in and has also been extensively used in IBS research. The necessity of a sensitive and specific biomarker for IBS is apparent, but despite the intensive research performed in this field, an appropriate biomarker is not yet available.

引用

页码：461 / 468

页数：8

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