Imprinting control within the compact Gnas locus

被引：18

作者：

Peters, J ^{[1
]}

Holmes, R

Monk, D

Beechey, CV

Moore, GE

Williamson, CM

机构：

[1] MRC, Mammalian Genet Unit, Harwell OX11 0RD, Oxon, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, Inst Reprod & Dev Biol, London, England

[3] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

来源：

CYTOGENETIC AND GENOME RESEARCH | 2006年 / 113卷 / 1-4期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1159/000090832

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mouse distal chromosome 2 was one of the earliest described imprinting regions. Maternal and paternal inheritance of the region is associated with opposite phenotypes affecting growth, development and behaviour. Mis-expression of proteins determined by the imprinted Gnas locus can account for the phenotypes. The imprinting domain in mouse distal chromosome 2 is small, comprising the Gnas locus. This locus is unusually complex, containing biallelic, maternally and paternally expressed transcripts that share exons. It also contains two germline differentially methylated regions that have the characteristics of imprinting control regions. One of these specifically controls the tissue-specific imprinting of the Gnas exon 1 transcript but does not affect the imprinting of other transcripts. Imprinting of other transcripts may be controlled by the other germline differentially methylated region by a mechanism involving antisense RNA.

引用

页码：194 / 201

页数：8

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