Rare Prenylated Isoflavones from Tephrosia calophylla

被引：0

作者：

Ganapaty, Seru ^{[1
]}

Nair, Vimal ^{[2
]}

Devi, Devarakonda Rama ^{[3
]}

Pannakal, Steve Thomas ^{[3
]}

Laatsch, Hartmut ^{[2
]}

Dittrich, Birger ^{[4
]}

机构：

[1] Gitam Univ, Gitam Inst Pharm, Visakhapatnam 530045, Andhra Pradesh, India

[2] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[3] Andhra Univ, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

[4] Inst Inorgan & Appl Chem, D-20146 Hamburg, Germany

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 07期

关键词：

Flavones; Auriculatin; Auriculasin; Isoflavones; X-ray diffraction; Invariom refinement; FLAVONOIDS; ANGUSTIFOLIA; INVARIOM;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical re-examination of the roots of T. calophylla led to the isolation of four isoflavones, namely 2',4',5-trihydroxy-6,7-(2 '',2 ''-dimethylchromene)-8-gamma,gamma-dimethylallylisoflavone (1a, auriculatin), 2',5-dihydroxy-6,7-(2 '',2 ''-dimethylchromene)4'-gamma,gamma-dimethylallyloxyisoflavone (2a, isoauriculatin), 3',4',5-trihydroxy-6,7-(2 '',2 ''-dimethylchromene)-8-gamma,gamma-dimethylallylisoflavone (1b, auriculasin), and 3',5-dihydroxy-6,7-(2 '',2 ''-dimethylchromene)-4'-gamma,gamma-dimethylallyl-oxyisoflavone (2b, isoauriculasin). Auriculasin and isoauriculasin are reported for the first time with full NMR assignments. All metabolites were fully characterized by ID and 2D NMR techniques including COSY, HSQC, HMBC experiments, mass spectra and in part on the basis of X-ray diffraction. Accurate 'invariom' refinements with aspherical scattering factors were carried out for 1a, 1b and 2a.

引用

页码：937 / 940

页数：4

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