Visceral Leishmaniasis and HIV Coinfection in the Mediterranean Region

被引：76

作者：

Monge-Maillo, Begona ^{[1
]}

Norman, Francesca F. ^{[1
]}

Cruz, Israel ^{[2
]}

Alvar, Jorge ^{[3
]}

Lopez-Velez, Rogelio ^{[1
]}

机构：

[1] Hosp Ramon & Cajal, Dept Infect Dis, E-28034 Madrid, Spain

[2] Inst Salud Carlos III, WHO Collaborating Ctr Leishmaniasis, Serv Parasitol, Ctr Nacl Microbiol, Madrid, Spain

[3] Drugs Neglected Dis Initiat DNDi, Visceral Leishmaniasis Program, Geneva, Switzerland

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2014年 / 8卷 / 08期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; AZAR DERMAL LEISHMANIASIS; REAL-TIME PCR; ACTIVE ANTIRETROVIRAL THERAPY; POLYMERASE-CHAIN-REACTION; LIPOSOMAL AMPHOTERICIN-B; LATEX AGGLUTINATION-TEST; INFECTED PATIENTS; SECONDARY PROPHYLAXIS; MEGLUMINE ANTIMONIATE;

D O I：

10.1371/journal.pntd.0003021

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region.

引用

页数：8

共 98 条

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