Perfect and Near-Perfect Adaptation in Cell Signaling

被引：110
作者：
Ferrell, James E., Jr. [1 ,2 ]
机构：
[1] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA
来源：
CELL SYSTEMS | 2016年 / 2卷 / 02期
关键词：
MAP KINASE; NEGATIVE-FEEDBACK; IN-VIVO; DYNAMICS; ERK; GENE; PHOSPHORYLATION; INACTIVATION; PHOSPHATASE; ROBUSTNESS;
D O I：
10.1016/j.cels.2016.02.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adaptation is an important basic feature of cellular regulation. Previous theoretical work has identified three types of circuits-negative feedback loops, incoherent feedforward systems, and state-dependent inactivation systems- that can achieve perfect or near-perfect adaptation. Recent work has added another strategy, termed antithetic integral feedback, to the list of motifs capable of robust perfect adaptation. Here, we discuss the properties, limitations, and biological relevance of each of these circuits.
引用
收藏
页码：62 / 67
页数：6
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