A degradable polydopamine coating based on disulfide-exchange reaction

被引：35

作者：

Hong, Daewha ^{[1
]}

Lee, Hojae ^{[1
]}

Kim, Beom Jin ^{[1
]}

Park, Taegyun ^{[1
]}

Choi, Ji Yu ^{[1
]}

Park, Matthew ^{[1
]}

Lee, Juno ^{[1
]}

Cho, Hyeoncheol ^{[1
]}

Hong, Seok-Pyo ^{[1
]}

Yang, Sung Ho ^{[2
]}

Jung, Sun Ho ^{[3
]}

Ko, Sung-Bo ^{[3
]}

Choi, Insung S. ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Cell Encapsulat Res, Taejon 34141, South Korea

[2] Korea Natl Univ Educ, Dept Chem Educ, Chungbuk 28173, South Korea

[3] Medigen Inc, Taejon 34045, South Korea

来源：

NANOSCALE | 2015年 / 7卷 / 47期

基金：

新加坡国家研究基金会;

关键词：

SURFACE-INITIATED POLYMERIZATION; BY-LAYER DEPOSITION; NEURAL INTERFACES; DRUG-DELIVERY; LIVING CELLS; THIN-FILMS; RELEASE; ENCAPSULATION; GLUTATHIONE; CHEMISTRY;

D O I：

10.1039/c5nr06460k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable to any kinds of substrates. In this paper, we report a dopamine derivative, which allows for both universal coating of various substrates and stimuli-responsive film degradation, inspired by mussel-adhesive proteins. Two dopamine moieties are linked together by the disulfide bond, the cleavage of which enables the programmed film degradation. Mechanistic analysis of the degradable films indicates that the initial cleavage of the disulfide linkage causes rapid uptake of water molecules, hydrating the films, which leads to rapid degradation. Our substrate-independent coating of degradable films provides an advanced tool for drug delivery systems, tissue engineering, and anti-fouling strategies.

引用

页码：20149 / 20154

页数：6

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