Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

被引：36

作者：

Franca, Paulo H. B. ^{[1
]}

Barbosa, Daniel P. ^{[2
]}

da Silva, Daniel L. ^{[1
]}

Ribeiro, Eurica A. N. ^{[2
]}

Santana, Antonio E. G. ^{[1
]}

Santos, Barbara V. O. ^{[3
]}

Barbosa-Filho, Jose M. ^{[3
]}

Quintans, Jullyana S. S. ^{[4
]}

Barreto, Rosana S. S. ^{[4
]}

Quintans-Junior, Lucindo J. ^{[4
]}

de Araujo-Junior, Joao X. ^{[1
,2
]}

机构：

[1] Univ Fed Alagoas, Inst Chem & Biotechnol, BR-57072970 Maceio, AL, Brazil

[2] Univ Fed Alagoas, Sch Nursing & Pharm, BR-57072970 Maceio, AL, Brazil

[3] Univ Fed Paraiba, Lab Pharmaceut Technol, BR-58051900 Joao Pessoa, Paraiba, Brazil

[4] Univ Fed Sergipe, Dept Physiol, BR-49000100 Sao Cristivai, SE, Brazil

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

NATURAL-PRODUCTS; BETA-CARBOLINE; TROPANE ALKALOIDS; SPONGE; DERIVATIVES; COMPILATION; FLAVONOIDS; INHIBITOR; ANALOGS; PLANTS;

D O I：

10.1155/2014/375423

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

引用

页数：12

共 91 条

[1] Alkylpyridine alkaloids from marine sponges. [J].

Almeida, AMP ;

Berlinck, RGS ;

Hajdu, E .

QUIMICA NOVA, 1997, 20 (02) :170-185

[2] The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity [J].

Alvarado, Stephenie ;

Roberts, Bracken F. ;

Wright, Amy E. ;

Chakrabarti, Debopam .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (05) :2362-2364

[3]

Amaral Flavia M.M., 2006, Rev. bras. farmacogn., V16, P696, DOI 10.1590/S0102-695X2006000500017

[4] Systematic UPLC-ESI-MS/MS Study on the Occurrence of Staurosporine and Derivatives in Associated Marine Microorganisms from Eudistoma vannamei [J].

Andreo, Marcio A. ;

Jimenez, Paula C. ;

Siebra, Josy B. C. N. ;

Costa-Lotufo, Leticia V. ;

Vessecchi, Ricardo ;

Niehues, Michael ;

Lopes, Joao L. C. ;

Lopes, Norberto P. .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2012, 23 (02) :335-343

[5] In vivo antimalarial activity of the beta-carboline alkaloid manzamine A [J].

Ang, KKH ;

Holmes, MJ ;

Higa, T ;

Hamann, MT ;

Kara, UAK .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1645-1649

[6]

[Anonymous], 2003, RECENT RES DEV PHYTO

[7]

[Anonymous], 2003, ARQUIVOS BRASILEIROS

[8]

[Anonymous], REV BRAS FARM

[9] Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp. [J].

Bao, Baoquan ;

Sun, Qishi ;

Yao, Xinsheng ;

Hong, Jongki ;

Lee, Chong-O. ;

Cho, Hee Young ;

Jung, Jee H. .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (01) :2-8

[10]

Barbosa Filho José M., 2006, Rev. bras. farmacogn., V16, P258, DOI 10.1590/S0102-695X2006000200021

← 1 2 3 4 5 6 7 8 9 10 →