Assembly of Layer-by-Layer Particles and Their Interactions with Biological Systems

被引：166
作者：
Yan, Yan [1 ]
Bjoenmalm, Mattias [1 ]
Caruso, Frank [1 ]
机构：
[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia
来源：
CHEMISTRY OF MATERIALS | 2014年 / 26卷 / 01期
基金：
澳大利亚研究理事会;
关键词：
layer-by-layer; polyelectrolyte capsules; multilayered particles; drug delivery; endocytosis; tumor targeting; POLYELECTROLYTE MULTILAYER CAPSULES; COLORECTAL-CANCER CELLS; POLYMER CAPSULES; DRUG-DELIVERY; THERAPEUTIC DELIVERY; GOLD NANOPARTICLES; HOLLOW CAPSULES; CARGO RELEASE; MICROCAPSULES; FABRICATION;
D O I：
10.1021/cm402126n
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Multilayered polymer particles with a wide range of properties can be precisely engineered via the layer-by-layer technique using a multitude of templates and materials. Such multilayered particles are emerging as a powerful platform for biomedical applications. In this short review, we provide an overview of developments in the engineering of multilayered polymer particles, and describe recent progress in their utilization in biological systems. Emphasis is placed on engineering strategies that achieve different biological objectives, ranging from triggered intracellular release of therapeutics to induction of protective immunity in vivo through particle-enabled vaccination. Finally, we provide a critical outlook of the key issues associated with the continued development of multilayered particles for biological applications.
引用
收藏
页码：452 / 460
页数：9
相关论文
共 78 条
  • [1] Albanese A, 2012, ANNU REV BIOMED ENG, V14, P1, DOI [10.1146/annurev-bioeng-071811-150124, 10.1146/annurev.bioeng-071811-150124]
  • [2] Fabrication and characterization of human serum albumin and L-α-dimyristoylphosphatidic acid microcapsules based on template technique
    An, ZH
    Tao, C
    Lu, G
    Möhwald, H
    Zheng, SP
    Cui, Y
    Li, JB
    [J]. CHEMISTRY OF MATERIALS, 2005, 17 (10) : 2514 - 2519
  • [3] Encapsulation of Bacterial Spores in Nanoorganized Polyelectrolyte Shells
    Balkundi, Shantanu S.
    Veerabadran, Nalinkanth G.
    Eby, D. Matthew
    Johnson, Glenn R.
    Lvov, Yuri M.
    [J]. LANGMUIR, 2009, 25 (24) : 14011 - 14016
  • [4] Redox-Active Polymer Microcapsules for the Delivery of a Survivin-Specific siRNA in Prostate Cancer Cells
    Becker, Alisa L.
    Orlotti, Nicola Ivan
    Folini, Marco
    Cavalieri, Francesca
    Zelikin, Alexander N.
    Johnston, Angus P. R.
    Zaffaroni, Nadia
    Caruso, Frank
    [J]. ACS NANO, 2011, 5 (02) : 1335 - 1344
  • [5] Layer-By-Layer-Assembled Capsules and Films for Therapeutic Delivery
    Becker, Alisa L.
    Johnston, Angus P. R.
    Caruso, Frank
    [J]. SMALL, 2010, 6 (17) : 1836 - 1852
  • [6] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating
    Caruso, F
    Caruso, RA
    Möhwald, H
    [J]. SCIENCE, 1998, 282 (5391) : 1111 - 1114
  • [7] Assembly and Functionalization of DNA-Polymer Microcapsules
    Cavalieri, Francesca
    Postma, Almar
    Lee, Lillian
    Caruso, Frank
    [J]. ACS NANO, 2009, 3 (01) : 234 - 240
  • [8] Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
    Cheng, Zhiliang
    Al Zaki, Ajlan
    Hui, James Z.
    Muzykantov, Vladimir R.
    Tsourkas, Andrew
    [J]. SCIENCE, 2012, 338 (6109) : 903 - 910
  • [9] Influence of size, surface, cell line, and kinetic properties on the specific binding of A33 antigen-targeted multilayered particles and capsules to colorectal cancer cells
    Cortez, Christina
    Tomaskovic-Crook, Eva
    Johnston, Angus P. R.
    Scott, Andrew M.
    Nice, Edouard C.
    Heath, Joan K.
    Caruso, Frank
    [J]. ACS NANO, 2007, 1 (02) : 93 - 102
  • [10] Targeting and uptake of multilayered particles to colorectal cancer cells
    Cortez, Christina
    Tomaskovic-Crook, Eva
    Johnston, Angus P. R.
    Radt, Benno
    Cody, Stephen H.
    Scott, Andrew M.
    Nice, Edouard C.
    Heath, Joan K.
    Caruso, Frank
    [J]. ADVANCED MATERIALS, 2006, 18 (15) : 1998 - +
12345678