Long-Term Follow-Up Trial of Oral Rifampin-Cotrimoxazole Combination versus Intravenous Cloxacillin in Treatment of Chronic Staphylococcal Osteomyelitis

被引：60
|
作者：
Euba, G. [1 ]
Murillo, O. [1 ]
Fernandez-Sabe, N. [1 ]
Mascaro, J. [1 ]
Cabo, J. [2 ]
Perez, A. [2 ]
Tubau, F. [3 ]
Verdaguer, R. [3 ]
Gudiol, F. [1 ]
Ariza, J. [1 ]
机构：
[1] Hosp Univ Bellvitge, Dept Infect Dis, IDIBELL, Barcelona 08907, Spain
[2] Hosp Univ Bellvitge, Dept Orthoped Surg, IDIBELL, Barcelona 08907, Spain
[3] Hosp Univ Bellvitge, Dept Microbiol, IDIBELL, Barcelona 08907, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期
关键词：
INFECTED ORTHOPEDIC IMPLANTS; TRIMETHOPRIM-SULFAMETHOXAZOLE; AUREUS; OFLOXACIN; INVIVO; ANTIBIOTICS; INVITRO; VANCOMYCIN; EFFICACY; AGENTS;
D O I：
10.1128/AAC.01504-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Oral therapies alternative to fluoroquinolones against staphylococcal chronic osteomyelitis have not been evaluated in comparative studies. Consecutive nonaxial Staphylococcus aureus chronic osteomyelitis cases were included in a comparative trial after debridement. Fifty patients were randomized: group A (n = 22) was treated with cloxacillin for 6 weeks intravenously plus 2 weeks orally (p.o.), and group B (n = 28) was treated with rifampin-cotrimoxazole for 8 weeks p.o. During follow-up (10 years), five relapses occurred: two (10%) in group A and three (11%) in group B. Foreign-body maintenance was associated with relapse (P = 0.016). Oral rifampin-cotrimoxazole treatment showed outcomes comparable to those for intravenous cloxacillin treatment.
引用
收藏
页码：2672 / 2676
页数：5
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