Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01

被引：40

作者：

Tian, Yongqi ^{[1
,2
]}

Qin, Xiaochu ^{[3
]}

Lin, Xiuping ^{[1
]}

Kaliyaperumal, Kumaravel ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Liu, Juan ^{[1
]}

Ju, Zhiran ^{[1
]}

Tu, Zhengchao ^{[3
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2015年 / 68卷 / 11期

基金：

中国国家自然科学基金;

关键词：

METABOLITES; DERIVATIVES;

D O I：

10.1038/ja.2015.55

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against He La, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 mu M, respectively.

引用

收藏

页码：703 / 706

页数：4

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