Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone

被引：12

作者：

Revanasiddappa, HD ^{[1
]}

Manju, B ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1999年 / 9卷 / 02期

关键词：

antidepressant drugs; spectrophotometry;

D O I：

10.1016/S0928-0987(99)00056-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A sensitive spectrophotometric method for the determination of amitriptyline hydrochloride, nortriptyline hydrochloride and doxepin hydrochloride in pure and dosage forms, is described. The method is based on the oxidative coupling of the drugs with 3-methylbenzothiazolin-2-one hydrazone in the presence of iron(III) chloride in 1 M hydrochloric acid. The commonly encountered excipients and additives do not interfere with the determinations. Results of the present method are comparable with those of official methods. The new method offers the advantage of simplicity and rapidity. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：221 / 225

页数：5

共 21 条

[1] MECHANISM OF OXIDATION OF 3-METHYL-2-BENZOTHIAZOLINONE HYDRAZONE BY POTASSIUM FERRICYANIDE IN AQUEOUS METHANOL
BARTSCH, RA
HUNIG, S
QUAST, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (20) : 6007 - &
[2] CHODKOWSKI J, 1992, CHEM ANAL-WARSAW, V37, P629
[3] CYR TD, 1992, J AOAC INT, V75, P804
[4] DEMBINSKI B, 1992, CHEM ANAL-WARSAW, V37, P495
[5] DETERMINATION OF AMITRIPTYLINE, IMIPRAMINE AND ORPHENADRINE IN ANTIDEPRESSANT DRUGS BY POTENTIOMETRY, SPECTROPHOTOMETRY AND ATOMIC-ABSORPTION SPECTROMETRY
ELNEMMA, EM
ELZAWAWY, FM
HASSAN, SSM
[J]. MIKROCHIMICA ACTA, 1993, 110 (1-3) : 79 - 88
[6] CONCURRENT LIQUID-CHROMATOGRAPHIC MEASUREMENT OF FLUOXETINE, AMITRIPTYLINE, IMIPRAMINE, AND THEIR ACTIVE METABOLITES NORFLUOXETINE, NORTRIPTYLINE, AND DESIPRAMINE IN PLASMA
ELYAZIGI, A
RAINES, DA
[J]. THERAPEUTIC DRUG MONITORING, 1993, 15 (04) : 305 - 309
[7] AUTOMATED COLORIMETRIC MICRODETERMINATION OF PHENOLS BY OXIDATIVE COUPLING WITH 3-METHYL-2-BENZOTHIAZOLINONE HYDRAZONE
FRIESTAD, HO
OTT, DE
GUNTHER, FA
[J]. ANALYTICAL CHEMISTRY, 1969, 41 (13) : 1750 - &
[8] HAERTER S, 1992, J CHROMATOGR-BIOMED, V116, P273
[9] CHARACTERIZATION OF AN INTERNAL-SURFACE REVERSED-PHASE SILICA SUPPORT FOR LIQUID-CHROMATOGRAPHY AND ITS APPLICATION TO ASSAYS OF DRUGS IN SERUM
HAGINAKA, J
WAKAI, J
YASUDA, N
YASUDA, H
KIMURA, Y
[J]. JOURNAL OF CHROMATOGRAPHY, 1990, 515 : 59 - 66
[10] KARTRITZKY AR, 1984, COMP HETEROCYCLIC CH, V7, P527

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