Structural biology: Proteins downhill all the way

被引：10

作者：

Kelly, Jeffery W. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

NATURE | 2006年 / 442卷 / 7100期

关键词：

D O I：

10.1038/442255a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hundreds of hydrogen atoms in a protein can be used as reporters to describe how the protein folds into and out of shape. The results challenge the dogma that this is always an all-or-nothing process.

引用

页码：255 / 256

页数：2

共 9 条

[1] FUNNELS, PATHWAYS, AND THE ENERGY LANDSCAPE OF PROTEIN-FOLDING - A SYNTHESIS [J].

BRYNGELSON, JD ;

ONUCHIC, JN ;

SOCCI, ND ;

WOLYNES, PG .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1995, 21 (03) :167-195

[2] THE FOLDING OF AN ENZYME .1. THEORY OF PROTEIN ENGINEERING ANALYSIS OF STABILITY AND PATHWAY OF PROTEIN FOLDING [J].

FERSHT, AR ;

MATOUSCHEK, A ;

SERRANO, L .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 224 (03) :771-782

[3] Experimental identification of downhill protein folding [J].

Garcia-Mira, MM ;

Sadqi, M ;

Fischer, N ;

Sanchez-Ruiz, JM ;

Muñoz, V .

SCIENCE, 2002, 298 (5601) :2191-2195

[4] Structure-function-folding relationship in a WW domain [J].

Jaeger, Marcus ;

Zhang, Yan ;

Bieschke, Jan ;

Nguyen, Houbi ;

Dendle, Maria ;

Bowman, Marianne E. ;

Noel, Joseph P. ;

Gruebele, Martin ;

Kelly, Jeffery W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) :10648-10653

[5] The protein folding 'speed limit' [J].

Kubelka, J ;

Hofrichter, J ;

Eaton, WA .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (01) :76-88

[6] Thermodynamics and kinetics of downhill protein folding investigated with a simple statistical mechanical model [J].

Muñoz, V .

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 2002, 90 (4-5) :1522-1528

[7] Observation of strange kinetics in protein folding [J].

Sabelko, J ;

Ervin, J ;

Gruebele, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6031-6036

[8] Atom-by-atom analysis of global downhill protein folding [J].

Sadqi, Mourad ;

Fushman, David ;

Munoz, Victor .

NATURE, 2006, 442 (7100) :317-321

[9] Folding at the speed limit [J].

Yang, WY ;

Gruebele, M .

NATURE, 2003, 423 (6936) :193-197

← 1 →