Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines

被引：15

作者：

Chiassai, Leonardo ^{[1
]}

Adam, Rosa ^{[1
]}

Drechslerova, Marcela ^{[1
]}

Ballesteros, Rafael ^{[1
]}

Abarca, Belen ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, Fac Farm, E-46100 Burjassot, Valencia, Spain

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2014年 / 164卷

关键词：

Triazolopyridines; Fluorine reagents; Lithiation reactions; Imidazopyridines; Trifluoromethyl pyridines; TRIAZOLOPYRIDINES; CHEMISTRY; ROUTE;

D O I：

10.1016/j.jfluchem.2014.05.001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

[1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：44 / 50

页数：7

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