Human growth hormone (hGH) is an autocrine growth factor and mitogen for lymphocytes

被引：0

作者：

Bulanova, EG ^{[1
]}

Budagyan, VN ^{[1
]}

Balura, AV ^{[1
]}

Agranat, VZ ^{[1
]}

Yarilin, AA ^{[1
]}

机构：

[1] MINIST PUBL HLTH RUSSIA,INST IMMUNOL,MOSCOW 115478,RUSSIA

来源：

ENDOCRINOLOGY AND METABOLISM | 1997年 / 4卷 / 03期

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D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the physiological effects of human growth hormone (hGH) is regulation of certain immune functions. In addition, lymphocytes can produce hGH which may serve as an autocrine growth factor. In this study, we have evaluated the role of hGH as a mitogen and autocrine growth factor. We have shown that hGH like other classic mitogens can stimulate lymphocyte proliferation, expression of activation antigens (receptors for interleukin-2 and transferrin) and secretion of interleukin-2 by lymphocytes (P<0.05). Activated lymphocytes themselves have the capacity to secrete hGH, with secretion peaking on the 7th day, while anti-hGH polyclonal serum inhibited proliferation of lymphocytes (P<0.05). These data provide evidence for the important role of hGH in lymphocyte activation and proliferation.

引用

页码：185 / 191

页数：7

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