Synthesis of N-vinyl-2-pyrrolidone-3-butenoic acid copolymers as drug carriers

被引：4
|
作者：
Borisenko, M. S. [1 ]
Zakharova, N. V. [1 ]
Tarabukina, E. B. [1 ]
Solovskii, M. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, Bolshoi Pr 31, St Petersburg 199004, Russia
来源：
RUSSIAN JOURNAL OF APPLIED CHEMISTRY | 2015年 / 88卷 / 11期
关键词：
Azobisisobutyronitrile - Composition characteristics - Copolymerisation - Drug carrier - N vinylpyrrolidone - N-vinyl-2-pyrrolidone - Radical copolymerization - Relative activities - Water soluble copolymers - γ-radiation;
D O I：
10.1134/S10704272150110099
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
New water-soluble copolymers of N-vinylpyrrolidone with 3-butenoic acid were prepared by radical copolymerization initiated with azobis(isobutyronitrile) or gamma-radiation. The relative activities of the monomers in copolymerization were determined. The distribution of the units in the copolymer macrochains was calculated. The composition, molecular and hydrodynamic characteristics, and acute toxicity of the copolymers were determined. The copolymers were used as carriers for rifampicin antibiotic.
引用
收藏
页码：1793 / 1799
页数：7
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