Synthesis of N-vinyl-2-pyrrolidone-3-butenoic acid copolymers as drug carriers

被引：4

作者：

Borisenko, M. S. ^{[1
]}

Zakharova, N. V. ^{[1
]}

Tarabukina, E. B. ^{[1
]}

Solovskii, M. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, Bolshoi Pr 31, St Petersburg 199004, Russia

来源：

RUSSIAN JOURNAL OF APPLIED CHEMISTRY | 2015年 / 88卷 / 11期

关键词：

Drug delivery;

D O I：

10.1134/S10704272150110099

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New water-soluble copolymers of N-vinylpyrrolidone with 3-butenoic acid were prepared by radical copolymerization initiated with azobis(isobutyronitrile) or gamma-radiation. The relative activities of the monomers in copolymerization were determined. The distribution of the units in the copolymer macrochains was calculated. The composition, molecular and hydrodynamic characteristics, and acute toxicity of the copolymers were determined. The copolymers were used as carriers for rifampicin antibiotic.

引用

页码：1793 / 1799

页数：7

共 12 条

[1]

Afinogenov G.E., 1993, ANTIMIKROBNYE POLIME

[2]

Andrews MJ, 1997, ATLA-ALTERN LAB ANIM, V25, P641

[3]

Bresler S.E., 1965, FIZIKA KHIMIYA MAKRO

[4] CHARACTERIZATION OF SEQUENCE DISTRIBUTION IN COPOLYMERS [J].

HARWOOD, HJ ;

RITCHEY, WM .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER LETTERS, 1964, 2 (6PB) :601-&

[5]

IVANOV VS, 1967, RADIATSIONNAYA POLIM

[6]

Kratochvil P., 1987, CLASSICAL LIGHT SCAT

[7]

Mashkovskii M. D, 2005, Lekarstvennye sredstva (Medicines), V15th

[8]

Panarin E.F., 2014, POLIMERY NOSITELI BI

[9]

PAVLOV GM, 1990, VYSOKOMOL SOEDIN A+, V32, P1190

[10]

Solovskii M.V., 1994, KHIM VYS ENERG, P375

← 1 2 →