Submicrometer axial resolution optical coherence tomography

被引：398
作者：
Povazay, B
Bizheva, K
Unterhuber, A
Hermann, B
Sattmann, H
Fercher, AF
Drexler, W
Apolonski, A
Wadsworth, WJ
Knight, JC
Russell, PSJ
Vetterlein, M
Scherzer, E
机构：
[1] Univ Vienna, Christian Doppler Lab, Inst Med Phys, A-1090 Vienna, Austria
[2] Vienna Univ Technol, Christian Doppler Lab, Photon Inst, Vienna, Austria
[3] Univ Bath, Dept Phys, Optoelect Grp, Bath, Avon, England
[4] Univ Vienna, Inst Histol & Embryol, A-1090 Vienna, Austria
来源：
OPTICS LETTERS | 2002年 / 27卷 / 20期
关键词：
D O I：
10.1364/OL.27.001800
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Optical coherence tomography (OCT) with unprecedented submicrometer axial resolution achieved by use of a photonic crystal fiber in combination with a compact sub-10-fs Ti:sapphire laser (Femtolasers Produktions) is demonstrated for what the authors believe is the first time. The emission spectrum ranges from 550 to 950 nm (lambda(c) = 725 nm, P-out = 27 mW), resulting in a free-space axial OCT resolution of similar to0.75 mum, corresponding to similar to0.5 mum in biological tissue. Submicrometer-resolution OCT is demonstrated in vitro on human colorectal adenocarcinoma cells HT-29. This novel light source has great potential for development of spectroscopic OCT because its spectrum covers the absorption bands of several biological chromophores. (C) 2002 Optical Society of America.
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收藏
页码：1800 / 1802
页数：3
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