Update on genetic predisposition to breast cancer

被引：5

作者：

Ahmed, Munaza ^{[1
]}

Lalloo, Fiona ^{[1
]}

Evans, D. Gareth ^{[1
]}

机构：

[1] Cent Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Dept Med Genet, Manchester M13 9WL, Lancs, England

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2009年 / 9卷 / 08期

关键词：

breast cancer; genes; penetrance; risk; GENOME-WIDE ASSOCIATION; ATAXIA-TELANGIECTASIA GENE; BRCA2; MUTATION; OVARIAN-CANCER; ESTROGEN-RECEPTOR; FAMILIAL BREAST; FANCONI-ANEMIA; SUSCEPTIBILITY GENE; CONFER SUSCEPTIBILITY; GERMLINE MUTATIONS;

D O I：

10.1586/ERA.09.38

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been evident for some time that individuals from some families exhibit a genetic predisposition to breast cancer. Since the discovery of the first breast cancer susceptibility gene, BRCA1 in the 1990s, much work has been carried out to identify further breast cancer susceptibility genes. This has led to the identification of another high-penetrance gene, BRCA2, a number of moderate-penetrance genes and, more recently, common low-penetrance genes and loci. The clinical benefit of the identification of such susceptibility genes and loci is in allowing an estimate of the risk of developing breast cancer in carriers. Ultimately, it is hoped that knowledge of an individual's genetic profile in relation to these genes may allow the use of targeted therapies to maximize efficacy in the treatment of breast cancer.

引用

页码：1103 / 1113

页数：11

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