Magnetic Resonance Imaging in Multiple Sclerosis

被引：89
作者：
Hemond, Christopher C.
Bakshi, Rohit [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Lab Neuroimaging Res,Dept Neurol, Partners Multiple Sclerosis Ctr,Ann Romney Ctr Ne, Boston, MA 02115 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 05期
关键词：
APPEARING WHITE-MATTER; DIFFUSION TENSOR TRACTOGRAPHY; CLINICALLY ISOLATED SYNDROMES; DOUBLE INVERSION-RECOVERY; BLOOD-BRAIN-BARRIER; SPINAL-CORD MRI; HIGH-FIELD MRI; GADOLINIUM-ENHANCING LESIONS; GRAY-MATTER; CORTICAL-LESIONS;
D O I：
10.1101/cshperspect.a028969
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Since its technical development in the early 1980s, magnetic resonance imaging (MRI) has quickly been adopted as an essential tool in supporting the diagnosis, longitudinal monitoring, evaluation of therapeutic response, and scientific investigations in multiple sclerosis (MS). The clinical usage of MRI has increased in parallel with technical innovations in the technique itself; the widespread adoption of clinically routine MRI at 1.5T has allowed sensitive qualitative and quantitative assessments of macroscopic central nervous system (CNS) inflammatory demyelinating lesions and tissue atrophy. However, conventional MRI lesion measures lack specificity for the underlying MS pathology and only weakly correlate with clinical status. Higher field strength units and newer, advanced MRI techniques offer increased sensitivity and specificity in the detection of disease activity and disease severity. This review summarizes the current status and future prospects regarding the role of MRI in the characterization of MS-related brain and spinal cord involvement.
引用
收藏
页数：21
相关论文
共 195 条
[41]   Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR [J].
de Graaf, Wolter L. ;
Zwanenburg, Jaco J. M. ;
Visser, Fredy ;
Wattjes, Mike P. ;
Pouwels, Petra J. W. ;
Geurts, Jeroen J. G. ;
Polman, Chris H. ;
Barkhof, Frederik ;
Luijten, Peter R. ;
Castelijns, Jonas A. .
EUROPEAN RADIOLOGY, 2012, 22 (01) :221-231
[42]   Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes [J].
De Stefano, N. ;
Giorgio, A. ;
Battaglini, M. ;
Rovaris, M. ;
Sormani, M. P. ;
Barkhof, F. ;
Korteweg, T. ;
Enzinger, C. ;
Fazekas, F. ;
Calabrese, M. ;
Dinacci, D. ;
Tedeschi, G. ;
Gass, A. ;
Montalban, X. ;
Rovira, A. ;
Thompson, A. ;
Comi, G. ;
Miller, D. H. ;
Filippi, M. .
NEUROLOGY, 2010, 74 (23) :1868-1876
[43]   Clinical Relevance of Brain Volume Measures in Multiple Sclerosis [J].
De Stefano, Nicola ;
Airas, Laura ;
Grigoriadis, Nikolaos ;
Mattle, Heinrich P. ;
O'Riordan, Jonathan ;
Oreja-Guevara, Celia ;
Sellebjerg, Finn ;
Stankoff, Bruno ;
Walczak, Agata ;
Wiendl, Heinz ;
Kieseier, Bernd C. .
CNS DRUGS, 2014, 28 (02) :147-156
[44]   Improving the Characterization of Radiologically Isolated Syndrome Suggestive of Multiple Sclerosis [J].
De Stefano, Nicola ;
Stromillo, Maria Laura ;
Rossi, Francesca ;
Battaglini, Marco ;
Giorgio, Antonio ;
Portaccio, Emilio ;
Hakiki, Bahia ;
Malentacchi, Gianmichele ;
Gasperini, Claudio ;
Santangelo, Mario ;
Bartolozzi, Maria Letizia ;
Sormani, Maria Pia ;
Federico, Antonio ;
Amato, Maria Pia .
PLOS ONE, 2011, 6 (04)
[45]   Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis [J].
Dineen, R. A. ;
Vilisaar, J. ;
Hlinka, J. ;
Bradshaw, C. M. ;
Morgan, P. S. ;
Constantinescu, C. S. ;
Auer, D. P. .
BRAIN, 2009, 132 :239-249
[46]  
Dousset V, 1999, AM J NEURORADIOL, V20, P223
[47]   Iron deposition in the gray matter in patients with relapse-remitting multiple sclerosis: A longitudinal study using three-dimensional (3D)-enhanced T2*-weighted angiography (ESWAN) [J].
Du, Silin ;
Sah, Shambhu K. ;
Zeng, Chun ;
Wang, Jingjie ;
Liu, Yi ;
Xiong, Hua ;
Li, Yongmei .
EUROPEAN JOURNAL OF RADIOLOGY, 2015, 84 (07) :1325-1332
[48]   Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T [J].
Dula, Adrienne N. ;
Pawate, Siddharama ;
Dortch, Richard D. ;
Barry, Robert L. ;
George-Durrett, Kristen M. ;
Lyttle, Bailey D. ;
Dethrage, Lindsey M. ;
Gore, John C. ;
Smith, Seth A. .
MULTIPLE SCLEROSIS JOURNAL, 2016, 22 (03) :320-328
[49]   MRI detection of hypointense brain lesions in patients with multiple sclerosis: T1 spin-echo vs. gradient-echo [J].
Dupuy, Sheena L. ;
Tauhid, Shahamat ;
Kim, Gloria ;
Chu, Renxin ;
Tummala, Subhash ;
Hurwitz, Shelley ;
Bakshi, Rohit .
EUROPEAN JOURNAL OF RADIOLOGY, 2015, 84 (08) :1564-1568
[50]   Investigation of leptomeningeal enhancement in MS A postcontrast FLAIR MRI study [J].
Eisele, Philipp ;
Griebe, Martin ;
Szabo, Kristina ;
Wolf, Marc E. ;
Alonso, Angelika ;
Engelhardt, Britta ;
Hennerici, Michael G. ;
Gass, Achim .
NEUROLOGY, 2015, 84 (08) :770-775
12345678910