The synthesis of unsymmetrical S1-(3′-O-thymidine-O-methanephosphonyl)-S2-p-nitrophenyl disulfides and their reactions with triphenylphosphine

被引：2

作者：

Chworos, A ^{[1
]}

Wozniak, LA ^{[1
]}

Stec, WJ ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, PL-90363 Lodz, Poland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 08期

关键词：

nucleic acid analogues; phosphonic acids; derivatives; disulfides; stereoselectivity;

D O I：

10.1016/S0040-4039(99)02247-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of thymidine 3'-methanephosphonothioic acid with p-nitrophenylsulfenyl chloride provides S-1 -(3'-O-thymidine-O-methanephosphonyl)-S-2-p-nitrophenyl disulfide which, in the presence of an excess of sulfenyl chloride and triphenylphosphine gives, in a stereospecific manner, thymidine 3'-(S-p-nitrophenyl methanephosphonodithioate). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1219 / 1222

页数：4