IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells

被引：2

作者：

Bie, Qingli ^{[1
]}

Zhang, Bin ^{[1
]}

Sun, Caixia ^{[2
]}

Ji, Xiaoyun ^{[1
]}

Barnie, Prince Amoah ^{[3
]}

Qi, Chen ^{[1
]}

Peng, Jingjing ^{[1
]}

Zhang, Danyi ^{[1
]}

Zheng, Dong ^{[1
]}

Su, Zhaoliang ^{[1
]}

Wang, Shengjun ^{[1
,4
]}

Xu, Huaxi ^{[1
,4
]}

机构：

[1] Jiangsu Univ, Sch Med, Dept Immunol, Zhenjiang, Jiangsu, Peoples R China

[2] Affiliated Hosp Jiangsu Univ, Dept Anesthesiol, Zhenjiang, Jiangsu, Peoples R China

[3] Univ Cape Coast, Sch Biol Sci, Dept Biomed & Forens Sci, Cape Coast, Ghana

[4] Jiangsu Univ, Sch Med, Key Lab Lab Med Jiangsu Prov, Zhenjiang, Jiangsu, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; IL-17B; mesenchymal stem cells (MSCs); stemness; NF-KAPPA-B; HELICOBACTER-PYLORI; PROMOTES; INTERLEUKIN-8; IMMUNITY; GROWTH;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes Nanog, Sox2, and Oct4 in mesenchymal stem cells and enhanced its tumor-promoting effect. The supernatant from cultured mesenchymal stem cells after treating with exogenous rIL-17B promoted the proliferation and migration of MGC-803, therefor suggesting that rIL-17B might promote mesenchymal stem cells to produce soluble factors. In addition, rIL-17B also activated the NF-kappa B, STAT3, beta-catenin pathway in mesenchymal stem cells. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.

引用

页码：18914 / 18923

页数：10

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