IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells

被引：2
作者：
Bie, Qingli [1 ]
Zhang, Bin [1 ]
Sun, Caixia [2 ]
Ji, Xiaoyun [1 ]
Barnie, Prince Amoah [3 ]
Qi, Chen [1 ]
Peng, Jingjing [1 ]
Zhang, Danyi [1 ]
Zheng, Dong [1 ]
Su, Zhaoliang [1 ]
Wang, Shengjun [1 ,4 ]
Xu, Huaxi [1 ,4 ]
机构：
[1] Jiangsu Univ, Sch Med, Dept Immunol, Zhenjiang, Jiangsu, Peoples R China
[2] Affiliated Hosp Jiangsu Univ, Dept Anesthesiol, Zhenjiang, Jiangsu, Peoples R China
[3] Univ Cape Coast, Sch Biol Sci, Dept Biomed & Forens Sci, Cape Coast, Ghana
[4] Jiangsu Univ, Sch Med, Key Lab Lab Med Jiangsu Prov, Zhenjiang, Jiangsu, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 12期
基金：
中国国家自然科学基金;
关键词：
gastric cancer; IL-17B; mesenchymal stem cells (MSCs); stemness; NF-KAPPA-B; HELICOBACTER-PYLORI; PROMOTES; INTERLEUKIN-8; IMMUNITY; GROWTH;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes Nanog, Sox2, and Oct4 in mesenchymal stem cells and enhanced its tumor-promoting effect. The supernatant from cultured mesenchymal stem cells after treating with exogenous rIL-17B promoted the proliferation and migration of MGC-803, therefor suggesting that rIL-17B might promote mesenchymal stem cells to produce soluble factors. In addition, rIL-17B also activated the NF-kappa B, STAT3, beta-catenin pathway in mesenchymal stem cells. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.
引用
收藏
页码：18914 / 18923
页数：10
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