The Impact of Selected Cytokines in the Follow-Up of Normal Pressure Hydrocephalus

被引：16

作者：

Sosvorova, L. ^{[1
]}

Mohapl, M. ^{[2
]}

Vcelak, J. ^{[3
]}

Hill, M. ^{[1
]}

Vitku, J. ^{[1
]}

Hampl, R. ^{[1
]}

机构：

[1] Inst Endocrinol, Dept Steroids & Proteofactors, Narodni 8, Prague 11694, Czech Republic

[2] Mil Univ Hosp Prague, Dept Neurosurg, Prague, Czech Republic

[3] Inst Endocrinol, Dept Mol Endocrinol, Prague 11694, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2015年 / 64卷

关键词：

Normal pressure hydrocephalus; Cytokine; Cerebrospinal fluid; Ventriculoperitoneal shunt; Neurodegeneration; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; INTERLEUKIN-6; LEVELS; FACTOR-ALPHA; BRAIN; INFLAMMATION; RECEPTOR; EXPRESSION; BETA; IL-1;

D O I：

10.33549/physiolres.933069

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) reabsorption and treated by surgical shunt insertion. The diagnostics is still complicated and the shunt effect is not durable; after several years, dementia may develop. In the clinical practice, biomarkers support the diagnostics as well as the further time course of many neurodegenerative diseases. Until recently, no reliable biomarker for NPH was evaluated. The attempt of this review was to make a survey concerning cytokines as possible NPH markers. Among all reviewed cytokines, the most promising are CSF IL-10 and IL-33, enabling to follow-up the disease progression and monitoring the effectiveness of the shunt insertion.

引用

页码：S283 / S290

页数：8

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