Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome

被引:3
作者
Shayan, Gilda [1 ]
Adamiak, Basia [2 ]
Choe, Leila H. [3 ,4 ]
Relkin, Norman [2 ]
Lee, Kelvin H. [1 ,3 ,4 ]
机构
[1] Cornell Univ, Dept Biomed Engn, Ithaca, NY USA
[2] Weill Cornell Med Coll, Dept Neurol & Neurosci, New York, NY USA
[3] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19711 USA
[4] Univ Delaware, Newark, DE 19711 USA
基金
美国国家卫生研究院;
关键词
Alzheimer's disease; Biomarker; Cerebrospinal fluid; Intravenous immunoglobulin; AMYLOID-BETA-PEPTIDE; MOUSE MODEL; DISEASE; IMMUNIZATION; BIOMARKERS; ANTIBODIES; TRANSFERRIN; CLEARANCE; DIAGNOSIS; PATHOLOGY;
D O I
10.1002/elps.201300609
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Intravenous immunoglobulin (IVIg) therapy has shown promise in the treatment of Alzheimer's disease (AD). In this study, serial cerebrospinal fluid (CSF) samples from a group of subjects with AD undergoing IVIg immunotherapy are analyzed to identify IVIg-related changes. CSF samples from eight subjects were collected before therapy, after 6 months of therapy, and after a 3-month drug washout period. Samples were analyzed using a gel-based proteomics strategy and IVIg-related changes were determined by gel spot percent volumes. An initial assessment of the data revealed consistent and considerable change in 69 spots. A statistical analysis revealed 79 protein spots with a significant change after 6 months; furthermore, in a subset of these (25), the percent volume change was either maintained or reversed in the washout samples. The proteins that showed a significant change during IVIg therapy, including Ig molecules, gelsolin, transferrin, and transthyretin, have been previously implicated in AD. This study provides preliminary findings regarding a group of CSF proteins that may be associated with the treatment of AD, as well as the potential use of IVIg as an AD immunotherapy.
引用
收藏
页码:1821 / 1827
页数:7
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