The Effects of Gastrointestinal Surgery on Gut Microbiota: Potential Contribution to Improved Insulin Sensitivity

被引：61

作者：

Aron-Wisnewsky, Judith ^{[1
,2
,3
]}

Clement, Karine ^{[1
,2
,3
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, UMR S 1166 1, ICAN,Nutri Team, F-75005 Paris, France

[2] Univ Paris 06, INSERM, UMR S U1166, Nutri Team, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, AP HP, ICAN, Dept Nutr, F-75013 Paris, France

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2014年 / 16卷 / 11期

关键词：

Bariatric surgery; Microbiota; Insulin sensitivity; Y GASTRIC BYPASS; TYPE-2 DIABETES REMISSION; DIET-INDUCED OBESITY; BETA-CELL FUNCTION; SERUM BILE-ACIDS; HIGH-FAT DIET; BARIATRIC SURGERY; WEIGHT-LOSS; AKKERMANSIA-MUCINIPHILA; PEPTIDE-1; RESPONSE;

D O I：

10.1007/s11883-014-0454-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Bariatric surgery induces weight loss and major improvement in insulin-resistance through many mechanisms some of which are weight independent. It is now well acknowledged that gut microbiota is involved in the development of obesity and its related metabolic diseases, at least in mice. However, its causal role in human obesity progression remains to be demonstrated. Few studies now pointed at changes in microbiota composition after bariatric surgery, suggesting links between gut microbiota switch and metabolic improvement observed after surgery. As such new potential mechanisms of actions have been proposed. The aim of this review is to describe microbiota modifications observed after bariatric surgery and its potential relationships with improved insulin resistance. We here list some hypotheses, which will need further demonstration.

引用

页码：1 / 11

页数：11

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