18-F-L 3,4-Dihydroxyphenylalanine PET/Computed Tomography in the Management of Congenital Hyperinsulinism

被引：10
作者：
States, Lisa J. [1 ,2 ]
Saade-Lemus, Sandra [1 ,3 ]
De Leon, Diva D. [2 ,4 ]
机构：
[1] Childrens Hosp Philadelphia, Radiol Dept, Sect Oncol Imaging, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[3] Roberts Ctr Pediat Res, Room 8255,2715 South St, Philadelphia, PA 19146 USA
[4] Childrens Hosp Philadelphia, Congenital Hyperinsulinism Ctr, Div Endocrinol & Diabet, 3500 Civ Ctr Blvd, Philadelphia, PA 19104 USA
来源：
PET CLINICS | 2020年 / 15卷 / 03期
关键词：
Congenital hyperinsulinism; Hyperinsulinism; F-DOPA; 18F]-FDOPA; Persistent hypoglycemia; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED TOMOGRAPHY; FOCAL FORM; DIAGNOSIS; INFANCY; HYPOGLYCEMIA; ACCURACY; PET/CT; SCAN; PREMEDICATION;
D O I：
10.1016/j.cpet.2020.03.004
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in neonates and infants. Several genetic mutations have been identified and are associated with 2 distinct histopathologic forms of disease: diffuse and focal. Targeted clinical evaluation to distinguish medically treatable disease from disease requiring surgical management can prevent life-threatening complications. Detection and localization of a surgically curable focal lesion using PET imaging with 18-F-L 3,4-dihydroxyphenylalanine ([18F]-FDOPA) has become standard of care. This article provides guidelines for the selection of patients who can benefit from [18F]-FDOPA-PET/computed tomography and protocols and tips used to diagnose a focal lesion of HI. © 2020 Elsevier Inc.
引用
收藏
页码：349 / 359
页数：11
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