Regulatory mechanisms of jaw bone and tooth development

被引:58
作者
Yuan, Yuan [1 ]
Chai, Yang [1 ]
机构
[1] Univ Southern Calif, Ctr Craniofacial Mol Biol, Los Angeles, CA 90007 USA
来源
VERTEBRATE SKELETAL DEVELOPMENT | 2019年 / 133卷
关键词
MESENCHYMAL STEM-CELLS; MANDIBULAR DISTRACTION OSTEOGENESIS; CRANIAL NEURAL CREST; MECKELS CARTILAGE; SONIC-HEDGEHOG; HOMEOTIC TRANSFORMATION; SIGNALING PATHWAYS; MIGRATORY BEHAVIOR; EARLY HINDBRAIN; MOUSE INCISORS;
D O I
10.1016/bs.ctdb.2018.12.013
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Jaw bones and teeth originate from the first pharyngeal arch and develop in closely related ways. Reciprocal epithelial-mesenchymal interactions are required for the early patterning and morphogenesis of both tissues. Here we review the cellular contribution during the development of the jaw bones and teeth. We also highlight signaling networks as well as transcription factors mediating tissue-tissue interactions that are essential for jaw bone and tooth development. Finally, we discuss the potential for stem cell mediated regenerative therapies to mitigate disorders and injuries that affect these organs.
引用
收藏
页码:91 / 118
页数:28
相关论文
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