Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines:: Tandutinib, erlotinib and gefitinib

被引：63

作者：

Knesl, Petr ^{[1
]}

Roeseling, Dirk ^{[1
]}

Jordis, Ulrich ^{[1
]}

机构：

[1] Vienna Tech Univ, Inst Appl Synth Chem, A-1060 Vienna, Austria

来源：

MOLECULES | 2006年 / 11卷 / 04期

关键词：

quinazolines; tyrosine kinase inhibitors;

D O I：

10.3390/11040286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutimb (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

引用

页码：286 / 297

页数：12

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