SYNTHESIS OF DIHYDROOXEPINS BY THE CYCLOADDITION OF 2-AMINO-4,5-DIHYDRO-3-FURANCARBONITRILES WITH DIMETHYL ACETYLENEDICARBOXYLATE

被引：0
作者：
Okabe, Fumi [1 ]
Maruoka, Hiroshi [1 ]
Masumoto, Eiichi [1 ]
Fujioka, Toshihiro [1 ]
Yamagata, Kenji [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
来源：
HETEROCYCLES | 2013年 / 87卷 / 11期
关键词：
BETA-ENAMINO ESTERS; HETEROCYCLIC ENAMINONITRILES; STRUCTURAL ELUCIDATION; CIGUATOXIN; TRITERPENOIDS; ZOAPATANOL; CHEMISTRY; SPONGE;
D O I：
10.3987/COM-13-12819
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient synthesis of dihydrooxepins is described. Treatment of readily available 2-amino-4,5-dihydro-3-furancarbonitriles with dimethyl acetylenedicarboxylate at room temperature caused smoothly a cycloaddition reaction, followed by a ring expansion, giving the corresponding dihydrooxepin derivatives.
引用
收藏
页码：2361 / 2368
页数：8
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