Nano-engineering block copolymer aggregates for drug delivery

被引：1175

作者：

Allen, C

Maysinger, D

Eisenberg, A

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

[2] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 1999年 / 16卷 / 1-4期

基金：

加拿大自然科学与工程研究理事会;

关键词：

block copolymer micelles; hydrophobic drugs; morphology of micelles;

D O I：

10.1016/S0927-7765(99)00058-2

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This review describes the properties of block copolymer micelles which influence their efficiency as drug delivery vehicles for hydrophobic drugs. The key performance related properties wt discuss are loading capacity, release kinetics, circulation time, biodistribution, size, size distribution and stability. Each of the properties is discussed in detail with specific attention given to the way in which they may be changed or controlled, the aim being to allow the reader to tailor-make block copolymer micelles for a particular application. In addition, the last section of the review focuses on the morphology of the micelles as another performance related property which, to this point, remains unexplored in this connection. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：3 / 27

页数：25

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