Different types of postmenopausal hormone therapy and mammographic density in Norwegian women

被引:18
作者
Bremnes, Yngve [1 ]
Ursin, Giske
Bjurstam, Nils
Lund, Eiliv
Gram, Inger Torhild
机构
[1] Univ Tromso, Inst Community Med, N-9037 Tromso, Norway
[2] Univ So Calif, Dept Prevent Med, Los Angeles, CA USA
[3] Univ Oslo, Dept Nutr, Oslo, Norway
[4] Univ Hosp N Norway, Ctr Breast Imaging, Dept Radiol, Tromso, Norway
关键词
postmenopausal hormone replacement therapy; mammography; breast density;
D O I
10.1002/ijc.22437
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Postmenopausal hormone therapy (HT) is associated with increased risk of breast cancer. The HTs used in Scandinavia is associated with higher risk estimates than those used in most other countries. Mammographic density is one of the strongest risk factors for breast cancer, and possibly an intermediate marker for breast cancer. We decided to examine the relationship between use of different types of HT and mammographic density in Norwegian women. Altogether, 1,007 postmenopausal participants in the governmental mammographic screening program were asked about current and previous HT use. Mammograms were classified according to percent and absolute mammographic density. Overall, current users of HT had on average 3.6% higher mean percent mammographic density when compared with never users (p < 0.001). After adjustment for age at screening, number of children and BMI in a multivariate model, women using the continuous estradiol (E-2) plus norethisterone acetate (NETA) combination had a mean percent mammographic density significantly higher than never users (6.1% absolute difference). Those using the continuous E-2 plus NETA combination had an 4.8% (absolute difference) higher mean percent mammographic density after < 5 years of use when compared with never users, while the corresponding number for >= 5 years of use was 7% (p-trend < 0.001). We found similar associations when absolute mammographic density was used as the outcome variable. In summary, our study shows a statistical significant positive dose-response association between current use of the continuous E-2 plus NETA combination and both measures of mammographic density. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:880 / 884
页数:5
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