Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q

被引：1

作者：

Qiu, Yong-Fu ^{[1
]}

Lu, Bin ^{[1
]}

Yan, Yi-Yu ^{[1
]}

Luo, Wan-Yue ^{[1
]}

Wang, Jin ^{[1
]}

Hu, Xiao ^{[2
]}

机构：

[1] Yancheng Teachers Univ, Jiangsu Key Lab Bioresources Saline Soils, Sch Pharm, Hope Ave South Rd 2, Yancheng 224007, Jiangsu, Peoples R China

[2] Yancheng Teachers Univ, Lib, Hope Ave South Rd 2, Yancheng 224007, Jiangsu, Peoples R China

来源：

CHEMICAL PAPERS | 2019年 / 73卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Coenzyme Q; 1; 4-Benzoquinone; Bromination; ANTIOXIDANT ACTIVITIES;

D O I：

10.1007/s11696-019-00826-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An 80% overall yield was demonstrated on a multi-gram scale.

引用

页码：2745 / 2748

页数：4

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