Stability and dynamics of virus capsids described by coarse-grained modeling

被引：200
作者：
Arkhipov, Anton
Freddolino, Peter L.
Schulten, Klaus [1 ]
机构：
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Phys, Urbana, IL 61801 USA
[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA
来源：
STRUCTURE | 2006年 / 14卷 / 12期
关键词：
D O I：
10.1016/j.str.2006.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.
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收藏
页码：1767 / 1777
页数：11
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