Stability and dynamics of virus capsids described by coarse-grained modeling

被引：200

作者：

Arkhipov, Anton

Freddolino, Peter L.

Schulten, Klaus ^{[1
]}

机构：

[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Phys, Urbana, IL 61801 USA

[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

来源：

STRUCTURE | 2006年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.str.2006.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.

引用

页码：1767 / 1777

页数：11

共 68 条

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