Occurrence of myeloproliferative disorder in patients with Noonan syndrome

被引：132

作者：

BaderMeunier, B

Tchernia, G

Mielot, F

Fontaine, JL

Thomas, C

Lyonnet, S

Lavergne, JM

Dommergues, JP

机构：

[1] HOP BICETRE, HEMATOL LAB, F-94270 LE KREMLIN BICETRE, FRANCE

[2] HOP NECKER ENFANTS MALAD, DEPT PEDIAT, PARIS, FRANCE

[3] TROUSSEAU HOSP, DEPT PEDIAT, PARIS, FRANCE

来源：

JOURNAL OF PEDIATRICS | 1997年 / 130卷 / 06期

关键词：

D O I：

10.1016/S0022-3476(97)70273-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report four cases of Noonan syndrome associated with chronic myelomonocytic leukemia in childhood, These children shared some hematologic features: thrombocytopenia, splenomegaly in the first months of life, occurrence of chronic myelomonocytic leukemia without abnormalities of the initial bone marrow karyotype, and, in three cases, improvement of the hematologic disease, A common pathophysiologic process in such patients is suggested.

引用

页码：885 / 889

页数：5

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