Synthesis, characterization, antibacterial activity, and interaction with DNA of the vanadyl-enrofloxacin complex

被引：73

作者：

Efthimiadou, Eleni K.

Katsaros, Nikos

Karaliota, Alexandra

Psomas, George ^{[1
]}

机构：

[1] NCSR Demokritos, Inst Phys Chem, GR-15310 Aghia Paraskevi, Greece

[2] Univ Athens, Fac Chem, Dept Inorgan Chem, GR-15701 Athens, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

关键词：

enrofloxacin; quinolones; vanadyl complex; biological activity; interaction with calf-thymus DNA; MIC;

D O I：

10.1016/j.bmcl.2006.12.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The neutral mononuclear vanadyl complex with the quinolone antibacterial drug enrofloxacin has been prepared and characterized with physicochemical and spectroscopic techniques and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1238 / 1242

页数：5

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