Insights Into circRNAs: Functional Roles in Lung Cancer Management and the Potential Mechanisms

被引：7

作者：

Feng, Bing ^{[1
]}

Zhou, Hao ^{[2
]}

Wang, Ting ^{[1
]}

Lin, Xinrong ^{[1
]}

Lai, Yongting ^{[3
]}

Chu, Xiaoyuan ^{[1
,2
,3
]}

Wang, Rui ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Med Oncol, Nanjing, Peoples R China

[2] Nanjing Med Univ, Jinling Hosp, Dept Med Oncol, Nanjing, Peoples R China

[3] Southern Med Univ, Jinling Hosp, Nanjing Sch Clin Med, Dept Med Oncol, Nanjing, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

circular RNAs (circRNAs); microRNAs (miRNAs); lung cancer; biomarker; prognosis; CIRCULAR RNA; PROMOTES PROLIFERATION; PROGRESSION; METASTASIS; EXPRESSION; MIGRATION; INVASION; TRANSLATION; SUPPRESSION; BIOGENESIS;

D O I：

10.3389/fcell.2021.636913

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lung cancer is the most prevalent cancer globally. It is also the leading cause of cancer-related death because of the late diagnosis and the frequent resistance to therapeutics. Therefore, it is impending to identify novel biomarkers and effective therapeutic targets to improve the clinical outcomes. Identified as a new class of RNAs, circular RNAs (circRNAs) derive from pre-mRNA back splicing with considerable stability and conservation. Accumulating research reveal that circRNAs can function as microRNA (miRNA) sponges, regulators of gene transcription and alternative splicing, as well as interact with RNA-binding proteins (RBPs), or even be translated into proteins directly. Currently, a large body of circRNAs have been demonstrated differentially expressed in physiological and pathological processes including cancer. In lung cancer, circRNAs play multiple roles in carcinogenesis, development, and response to different therapies, indicating their potential as diagnostic and prognostic biomarkers as well as novel therapeutics. In this review, we summarize the multi-faceted functions of circRNAs in lung cancer and the underlying mechanisms, together with the possible future of these discoveries in clinical application.

引用

页数：12

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