Advances in the Isolation of Specific Monoclonal Rabbit Antibodies

被引：19

作者：

Zhang, Zaibao ^{[1
,2
]}

Liu, Huijuan ^{[1
,2
]}

Guan, Qian ^{[3
]}

Wang, Lei ^{[1
,2
]}

Yuan, Hongyu ^{[1
,2
]}

机构：

[1] Xinyang Normal Univ, Inst Conservat & Utilizat Agrobioresources Dabie, Xinyang, Peoples R China

[2] Xinyang Normal Univ, Coll Life Sci, Xinyang, Peoples R China

[3] Southern Med Univ, State Key Lab Organ Failure Res, Natl Clin Res Ctr Kidney Dis, Div Nephrol,Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

rabbit antibody repertoire; rabbit monoclonal antibody; hybridoma; phage display; single B cell antibody technology; HEAVY-CHAIN LOCUS; PHAGE DISPLAY; SEQUENCE-ANALYSIS; RAPID GENERATION; B-CELL; REPERTOIRE; LIBRARIES; SURFACE; HYBRIDOMAS; EXPRESSION;

D O I：

10.3389/fimmu.2017.00494

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit antibody repertoire and summarizes methods of hybridoma technologies, phage display platform, and single B cell antibody technologies. With advances in antibody function and repertoire analysis, rabbit mAbs will be widely used in therapeutic applications in the coming years.

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