Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines

被引:146
作者
Hong, Catherine H. L. [1 ]
Gueiros, Luiz Alcino [2 ]
Fulton, Janet S. [3 ]
Cheng, Karis Kin Fong [4 ]
Kandwal, Abhishek [5 ]
Galiti, Dimitra [6 ]
Fall-Dickson, Jane M. [7 ]
Johansen, Jorgen [8 ]
Ameringer, Suzanne [9 ]
Kataoka, Tomoko [10 ]
Weikel, Dianna [11 ]
Eilers, June [12 ]
Ranna, Vinasha [13 ]
Vaddi, Anusha [14 ]
Lalla, Rajesh V. [15 ]
Bossi, Paolo [16 ]
Elad, Sharon [17 ]
机构
[1] Natl Univ Singapore, Discipline Orthodont & Paediat Dent, Fac Dent, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore
[2] Univ Fed Pernambuco, Oral Med Unit, Recife, PE, Brazil
[3] Indiana Univ, Sch Nursing, Indianapolis, IN 46204 USA
[4] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Singapore, Singapore
[5] Swami Rama Himalayan Univ, Canc Res Inst, Himalayan Inst Med Sci, Dehra Dun, India
[6] Univ Athens, Dent Sch, Athens, Greece
[7] Georgetown Univ, Sch Nursing & Hlth Studies, Dept Profess Nursing Practice, Washington, DC USA
[8] Odense Univ Hosp, Dept Oncol, Odense, Denmark
[9] Virginia Commonwealth Univ, Sch Nursing, Richmond, VA USA
[10] Natl Canc Ctr, Multiinst Clin Trials Sect, Res Management Div, Clin Res Support Off, Tokyo, Japan
[11] Univ Maryland, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
[12] Univ Nebraska Med Ctr, Coll Nursing, Omaha Div, 985330 Nebraska Med Ctr, Omaha, NE 68198 USA
[13] Mt Sinai Hosp, Dept Oral & Maxillofacial Surg, New York, NY 10029 USA
[14] Univ Rochester, Eastman Inst Oral Hlth, Oral Med, Rochester, NY USA
[15] Univ Connecticut Hlth, Sect Oral Med, Farmington, CT USA
[16] Univ Brescia, ASST Spedali Civili, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy
[17] Univ Rochester, Med Ctr, Eastman Inst Oral Hlth, Oral Med, Rochester, NY 14642 USA
关键词
Basic oral care; Chlorhexidine; Oral mucositis; Sodium bicarbonate; Saline; Patient education; Dental care; Guidelines; Cancer; STEM-CELL TRANSPLANTATION; DOUBLE-BLIND; ACUTE-LEUKEMIA; NECK-CANCER; MARROW-TRANSPLANTATION; MOUTH CARE; CHLORHEXIDINE PROPHYLAXIS; POVIDONE-IODINE; HEALTH CARE; CHEMOTHERAPY;
D O I
10.1007/s00520-019-04848-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose The aim of this study was to update the clinical practice guidelines for the use of basic oral care (BOC) interventions for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention in each cancer treatment setting was assigned an evidence level. The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results A total of 17 new papers across six interventions were examined and merged with a previous database. Based on the literature, the following guidelines were possible. The panel suggests that the implementation of multi-agent combination oral care protocols is beneficial for the prevention of OM during chemotherapy, head and neck (H&N) radiation therapy (RT), and hematopoietic stem cell transplantation (Level of Evidence III). The panel suggests that chlorhexidine not be used to prevent OM in patients undergoing H&N RT (Level of Evidence III). No guideline was possible for professional oral care, patient education, saline, and sodium bicarbonate, and expert opinion complemented these guidelines. Conclusions The evidence supports the use of multi-agent combination oral care protocols in the specific populations listed above. Additional well-designed research is needed on the other BOC interventions prior to guideline formulation.
引用
收藏
页码:3949 / 3967
页数:19
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